The beginning of the official process will alert athletics officials and West Ham United FC who are known to be interested in the venue.
"The Olympic Stadium is a truly iconic structure that should be a focal point for sport and community-led events including schools, clubs and creative and social enterprises," said Olympic Park legacy Company (OPLC) chief executive Andrew Altman.
"A successful Stadium legacy is vital to the Company's long term aspirations for the Olympic Park. We want to provide local people with significant improvements in health and well-being, education, skills and training, job opportunities, cultural entitlements, housing, social integration and environment."
Organisations or consortia, interested in managing, operating in, or locating to the Stadium after the London 2012 Games will have eight weeks to come forward with their interest and initial views. This could include "sporting, community, education, visitor attraction and commercial uses" according to OPLC.
The next stage of securing the venue's legacy will take place in June, which could include a public procurement exercise.
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