The activity will see 10 carved wooden doors hang in pubs and other venues near filming locations across Northern Ireland.
A new door will be unveiled each week, and will depict key scenes from the most recent episode that aired on television, as well as include key symbols from the show. The first door was unveiled on Tuesday (26 April), and can be found at The Cuan guest inn in Strangford.
The doors are carved from trees that have been blown down in Storm Gertrude at the Dark Hedges in Co Antrim, the backdrop for the programme's Kingsroad scene.
The campaign aims to showcase Northern Ireland to the world, by highlighting that scenes from all six Game of Thrones series' have been filmed in the country. It will continue until the end of June, when the series comes to an end.
A Game of Thrones stamp for mail posted in Northern Ireland will be available throughout the campaign, and Tourism Ireland plans to release related short films and images via social and YouTube in ten countries, including Great Britain, the United States, Canada, Australia, France, Germany, Spain, Italy, the Netherlands and Scandinavia.
Niall Gibbsons, CEO, Tourism Ireland, said: "We are delighted to continue our partnership with HBO in 2016, to highlight Northern Ireland – through the exciting events of Game of Thrones – on the global stage. TV and film are recognised as strong influencers on travellers everywhere and the stellar popularity of Game of Thrones is a fantastic opportunity for us to promote Northern Ireland to a huge audience of potential visitors.
"Our latest campaign is a fun and innovative way to bring the destination to the attention of Game of Thrones fans everywhere – they will see our ads, spiking their curiosity about the landscapes and locations featured in the series and inspiring them to come and explore them for themselves."
Sky Atlantic celebrated the programme's return to the network by enlisting two four-piece orchestras to take over train stations in London on Monday (25 April).