The three-day festival, which kicks off today (28 August), will see the brands create a 2,000 person smiley face within the artists Smile High Club on the final day (30 August).
Festival-goers have been invited to take part in the stunt by registering online in the lead up to the festival, which will also see them go in the draw to win Creamfields 2016 tickets and a Samsung Galaxy S6.
Samsung and Vodafone will additionally activate a 12x12 metre branded space with key features, including a silent disco, interactive photo booth and charging area.
The campaign is designed to promote the new Samsung Galaxy S6 and S6 Edge phones through the Vodafone channel.
The brands similarly teamed up to activate at the inaugural Creamfields Ibiza on 1 August.
Agency Undercurrent is responsible for the creative, delivery and stakeholder management of the campaign, which also encompasses retail and online activity.
Vodka brand Smirnoff is unveiling its Smirnoff House experience at the festival, meanwhile other brands set to activate include Somersby Cider, Sure and Pepsi Max.
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