The experience will take place 800ft above London with 360-degree views of the city, on Saturday 2 July.
Reztron will be taking over levels 69 and 72 of The Shard for the gaming skybar, which will celebrate the classic gaming console.
There will popular games available to play on the Sega Mega Drive, such as Golden Axe, Alien Storm, Revenge of Shinobi, OutRun, After Burner, Space Harrier, Sonic 2, Micro Machines, Streets of Rage, Street Fighter II and Mortal Kombat.
In celebration of Sonic the Hedgehog's 25th Anniversary there will also be a Sonic speed run competition on a large projector screen via the original Mega Drive console.
People will also be able to enjoy classic rock, pop, hip hop, r 'n' b and dance music provided by a three DJ set silent disco.
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