The agency was responsible for the fan fest event at Trafalgar Square last Saturday (3 October), and it is delivering the NFL on Regent Street event, which sees the street closed to traffic for the day, on 24 October.
Paul Southby, senior project director at Wasserman Experience, told Event: "We are hosting fan events before each game to celebrate the NFL. There are guest appearances from players, as well as bespoke food and drink.
"Visitors can take part in interactive games including throwing and kicking experiences, and The Lab puts fans through skills and drills."
The New York Jets played the Miami Dolphins last Sunday (4 October), meanwhile Buffalo Bills take on the Jacksonville Jaguars on 25 October, and the Detroit Lions compete against the Kansas City Chiefs on 1 November.
Brands including Budweiser are activating around the NFL series, meanwhile Marriot Rewards will activate an interactive football challenge for the Regent Street fan fest, with more details to be unveiled in due course.