The Worn Wear tour will visit The Brokedown Palace shop in Boxpark from 26-27 April and Spitalfields on 28 April.
The brand is inviting consumers to bring items from any brand that have broken zips, tears or missing buttons in to the store for Patagonia's sewing team to fix.
Thanks to their industrial-grade Juki sewing machines, staff are able to mend around 20 garmets each day. If items are dirty, they will show visitors how to fix the wares themselves. Food and drinks will also be served at the pop-up.
The 50-stop tour, which is now in its third year, officially began in Santa Monica, Los Angeles on 20 March. Its European leg includes countries such as Germany, Italy, France and Austria.
The brand's first UK destination was George Fisher in Keswick last week (15-16 April). The tour is currently passing through Shropshire and Stevenage, and will finish at surf shop Down The Line in Hayle.
The brand believes repairing garments, rather than throwing them into landfill, is a radical act in the age of fast fashion.
Rose Marcario, CEO, Patagonia said: "Building a product that lasts and can be repaired is the very first and most critical step toward limiting our footprint on the environment.
"We want to empower our customers to be owners, not just consumers. It’s a simple but critical message: keep your gear in action longer and take some pressure off our planet."
Earlier this week, H&M unveiled a window display powered by shoppers' footsteps for World Recycle Week.