The free event will see the Regent Street store open from 5-8pm for special activities across its various departments.
Those who attend can expect to sip on drinks from Bloom Gin and dance along to music from guest DJ Vogue Williams. There will also be 'personalisation stations' showcasing accessories, as well as tarot reading services, and opportunities for attendees to win prizes.
Ten per cent of all sales will go to the charity, while Liberty Loyalty customers will receive a 10% discount and double points on their spendings.
The store ran a similar event last November, where attendees could win all of the products displayed in one of its windows.
The Women of Influence campaign supports female scientists who have received a Fellowship Award from Cancer Research UK. It aims to raise £1 million to give women in the field financial support and mentoring from business leaders.
Earlier this week Liberty announced it would host the launch of Häagen Dazs' limited editon floral ice creams on 11 April, which will be available for purchase exclusively within the store.
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