The privately-owned Georgian country house will allow members of the public to access the normally private estate for the first time.
The series of open events will include cream tea tours and open-air cinema screenings for films including Quartet on 21 June, as well as Les Miserables the day before.
Hamish Shephard, partner of Hedsor House, said: "As a family we are immensely proud of this fantastic house which has such a wonderful heritage and such magnificent grounds.
"Properties like Hedsor are extremely expensive to maintain which is why five years ago we embarked on our business venture to transform it into a specialist events and wedding venue."
He added that even though the venue’s profile has been raised as a result of featuring in movies and TV programmes, Hedsor House has the ability to be adapted to suit a number of occasions.
The Shephard family will be marking the fifth anniversary of Hedsor House by planting a Lebanon Cedar tree near the house.
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