As part of the Great Game Challenge, people in the UK, US, Canada, France and Germany can enter their design for the chance to see it transformed into a new face-to-face board game.
The winner will also receive $25,000 (£17,566) and a trip to Hasbro's Rhode Island headquarters, where they will make their game with the company.
Submissions are open until the 15 May. After this point, experts from Hasbro will whittle down the entrants to 15 semi-finalists, who will make a prototype of their game.
The final five will launch their own campaign on Indiegogo, which will run from 18 October to 14 November.
Each of the five will also receive a £1,400 prize and mentoring from both Hasbro and Indiegogo. The final winner will be announced in late 2016.
The competition first began in 2015, where The Mr Toast Game was chosen from more than 500 entries. Its creator, Dan Godsell, is now working with Hasbro to launch it into the US market later this year.
Brian Chapman, head of design and development at Hasbro, said: "We are looking for games with a unique narrative and visual style which can provide a fun opportunity for storytelling through gaming and we are excited to see the ideas from game designers around the world."
Jerry Needel, senior vice president of corporate partnerships at Indiegogo, added: "It was incredibly impressive to see how quickly Hasbro was able to discover a new game idea to bring to market through our first gaming challenge in 2015.
"We are very excited to continue our Enterprise Crowdfunding relationship with Hasbro and look forward to seeing what we can collectively create in this next installment."
Earlier this month (2-3 April), Hasbro teamed up with the London Games Festival to transform Trafalgar Square into a giant Monopoly board.
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