McAlinden brings more than 15 years of experience to the agency, and alongside ODD has held creative leadership roles at Ogilvy Action and Geometry Global.
Over the course of his career McAlinden has delivered projects for brands such as Coca-Cola, HSBC, Vodafone, Dr. Martens and BP.
The new role will see McAlinden handle all creative output for the agency’s clients, which include Arla Foods UK, Heineken UK, William Grant and Sons, UEFA, Wimbledon, Lufthansa and Coral.
Other responsibilies will include leading creative thinking among staff and enhancing the agency’s overall strategic offering.
McAlinden will sit within the agency’s senior leadership team to help drive growth, and is to report into its managing partners, David Atkinson and Jason Nicholas.
Nicholas said: "Greg’s appointment marks a significant development for Space. We are being increasingly challenged by our clients to help them emotionally connect with their audiences anywhere that influences their choice of brand; on screens, in print, in-store, live or virtual.
"In Greg, we have found a proven creative leader who has the intelligence, creativity and drive to embrace these challenges and deliver compelling solutions for our clients."
McAlinden added: "Space is a creative agency with so much going for it. It works with great clients, has a hugely talented team and has an excellent creative track record, which I am really looking forward to building upon.
"What impresses me about Space is its clear sense of purpose, to move people to choose its clients’ brands, and its belief that creativity that moves seamlessly between people, places and spaces builds closer, more valued relationships for brands."
Space recently devised a three-month trophy train tour for the Euro 2016 on behalf of UFEA, which wil continue until June.