Motorists are advised to avoid central London and Olympic venues from mid-July, when London will become a "massive sporting and cultural venue" for the Games.
The Olympic Route Network (ORN) will be in operation from 25 July, two days before the Olympic opening ceremony, which marks the start of the Games.
The ORN is a 109-mile system of roads linking Games venues together. Around 30 miles of the route - known as Games Lanes - are reserved for athletes, officials, media and some sponsors, but all drivers can use the rest of the roads.
From 1 July a large programme of temporary changes will be put in place, such as road markings, temporary traffic islands, barriers to simplify junctions and adjustments to over 1,300 sets of traffic signals. Planned roadworks will be banned on the ORN and on all A and B roads in London.
Once events are completed at a venue, the ORN will be removed from that area.
The ORN will stop operating a couple of days after the Games and the smaller Paralympic Route Network (PRN) come into operation a few days before the Paralympic Games.
All Olympic host cities are required to create an ORN to ensure that athletes, officials and media get to Games events on time.
TfL reiterated its advice to plan ahead for travel during the Olympic period using its Get Ahead of the Games website, as congestion on each day will be different.
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